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Builders & open source

Matthew McPartlon

Co-founder, Chai Discovery

Matthew McPartlon is one of the four co-founders of Chai Discovery, which the company's announcements describe as founded in 2024 by Joshua Meier, Jack Dent, Matthew McPartlon and Jacques Boitreaud to design new medicines with AI. McPartlon is a named author of the Chai-1 technical report (2024), whose model predicts the structures of molecular complexes, and of the Chai-2 report (2025) on zero-shot antibody design.123

At a glance

Current role
Co-founder
Sector
Company
Work listed
2
Sources cited
5
Profile reviewed

Chai Discovery

McPartlon co-founded Chai Discovery in 2024 with Joshua Meier, Jack Dent and Jacques Boitreaud; the company builds models that reason about biological structure and function and generate new molecular designs. Chai's 2026 announcements of collaborations with Novartis and argenx name McPartlon among the founders.14

Research

McPartlon is an author of the Chai-1 technical report, posted to bioRxiv in October 2024, which the open-source chai-lab repository asks users to cite when using the model. McPartlon is also an author of the Chai-2 technical report on zero-shot antibody design, posted in July 2025.253

Work and contributions

  • Chai-1 Open weights

    Named author of "Chai-1: Decoding the molecular interactions of life" (2024), the technical report for the model whose weights the chai-lab package uses.25

  • Chai-2 Proprietary product

    Named author of "Zero-shot antibody design in a 24-well plate" (2025), the Chai-2 technical report.3

Timeline

  1. Co-founded Chai Discovery with Joshua Meier, Jack Dent and Jacques Boitreaud.1
  2. Co-authored the Chai-1 technical report on molecular structure prediction.2
  3. Co-authored the Chai-2 technical report on zero-shot antibody design.3

Where they work

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References

5 sources · profile reviewed Oct 22, 2026 · data updated Oct 22, 2026

  1. Chai Discovery news — collaboration with argenx (July 2026, includes founder list)Chai Discovery · Announcement · published Jul 15, 2026 · accessed Oct 22, 2026
  2. Chai-1: Decoding the molecular interactions of life (bioRxiv 10.1101/2024.10.10.615955; Crossref record)Cold Spring Harbor Laboratory (bioRxiv, via Crossref) · Paper · published Oct 11, 2024 · accessed Oct 22, 2026
  3. Zero-shot antibody design in a 24-well plate (bioRxiv 10.1101/2025.07.05.663018; Crossref record)Cold Spring Harbor Laboratory (bioRxiv, via Crossref) · Paper · published Jul 6, 2025 · accessed Oct 22, 2026
  4. Chai Discovery news — collaboration with Novartis (includes founder list)Chai Discovery · Announcement · accessed Oct 22, 2026
  5. chaidiscovery/chai-lab README (citations)Chai Discovery (GitHub repository) · Repository · accessed Oct 22, 2026